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US 2026/0274928 A1Published application
Antibodies that bind to multiple sarbecoviruses
AssigneeVir Biotechnology, Inc.
InventorsPaul M. Chang, Justin W. Chartron, Davide Corti, Anna De Marco, Frederick S. Lee, Barry D. Olafson, Dora Pinto, Laura Rosen, Gyorgy Snell
Life of this patent
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Abstract
The instant disclosure provides antibodies and antigen-binding fragments thereof that can bind to S proteins of sarbecoviruses (including, in some embodiments, multiple sarbecoviruses) and, in certain embodiments, are capable of neutralizing infection by multiple sarbecoviruses.
Claims25
An antibody, or an antigen-binding fragment,
- comprising a heavy chain variable domain (VH) comprising a complementarity determining region (CDR) H1, CDRH2, and a CDRH3, and a light chain variable domain (VL) comprising a CDRL1, CDRL2, CDRL3, wherein;
- (i) the CDRH1, CDRH2, CDRH3, CDRL1, CDRL2, and CDRL3 are according to SEQ ID NOs:
- 68, 171, 70, 72, 73, and 114, respectively;
- or
- (ii) the CDRH1, CDRH2, CDRH3, CDRL1, CDRL2, and CDRL3 are according to SEQ ID NOs:
- 68, 215 or 216, 70, 72, 73, and 114, respectively.
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An antibody or antigen-binding fragment comprising:
- a first VH and a first VL;
- and a second VH and a second VL, wherein the first VH and first VL comprise an amino acid sequence having at least 85% identity to the amino acid sequence according to SEQ ID NO:
- 184, and an amino acid sequence having at least 85% identity to the amino acid sequence according to SEQ ID NO:
- 113, respectively;
- wherein the first VH and the first VL are different from the second VH and second VL;
- wherein the first VH and the first VL together form a first antigen-binding site;
- and wherein the second VH and the second VL together form a second antigen-binding site.
4 more elements
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Dependencies are inferred from the claim text.