Method for producing polypeptide

A method for producing a polypeptide comprising an elastin-like block peptide sequence that comprises a G sequence block consisting of (SEQ ID NO:

• 1:
• X1GGX2G)n, wherein each X1 is the same or different and represents V or L, each X2 is the same or different and represents V or L, and n represents an integer of 2 or more, and a P sequence block consisting of (SEQ ID NO:
• 2:
• VPGX3G)m, wherein each X3 is the same or different and represents any amino acid, and m represents an integer of 5 or more,
• the method comprising:
• (a) synthesizing the polypeptide and/or split fragments of the polypeptide by solid-phase synthesis;
• and/or
• (b) linking terminal regions of the multiple split fragments of the polypeptide by a chemical reaction,
• wherein when the method comprises step (b), the chemical reaction in step (b) is a reaction between a thiol group of an amino acid residue a in the terminal region of one split fragment a and a vinyl group or a maleimide group added to an amino acid residue b in the terminal region of the other split fragment b.