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US 2026/0274911 A1Published application
Modified Myoferlin Protein and Method of Use Thereof to Increase Nanoparticle Payload Release
OwnerKevin Morrisinventor
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Abstract
A modified myoferlin protein capable of being packaged into extracellular vesicles (EVs) to facilitate release of EV payloads into recipient cells. The modified myoferlin protein enhances the release of payload at the targeted site. The present invention further provides a modified myoferlin-encapsulating nanoparticle comprising an exosome encapsulating any embodiment of the modified myoferlin of the present invention and one or more cargo RNAs to enhance release of the cargo RNAs at the targeted site.
Claims23
A modified myoferlin protein comprising one or more C2 domains and one or more non-C2 domains
- wherein the one or more C2 domains comprises a C2A domain, a C2B domain, a C2C domain, a C2D domain, a C2E domain, a C2F domain, a C2G domain, or a combination thereof;
- wherein the one or more non-C2 domain comprise a transmembrane domain, a FerA domain, a FerB domain, a DysFN-1, domain, a DysFN-2 domain, or a combination thereof;
- and
- wherein the modified myoferlin protein does not comprise one or more of C2B domain, C2C domain, C2D domain and/or C2E domains.
1 more element
Dependencies are inferred from the claim text.