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US 2026/0274886 A1Published application
Crystalline forms of a farnesoid x receptor agonist
AssigneeAlfasigma S.P.A.
InventorGabriel M. GALVIN
Life of this patent
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Abstract
Provided are crystalline forms of a farnesoid x receptor agonist, compositions comprising the same, and methods of making and using such crystalline forms.
Claims25
A tert-butyl methyl ether solvate of 3α,7α,11β-trihydroxy-6α-ethyl-5β-cholan-24-oic acid.
A crystalline form of 3α,7α,11β-trihydroxy-6α-ethyl-5β-cholan-24-oic acid, wherein the crystalline form exhibits at least one of an XRPD pattern comprising at least three of the following 2-theta (°) values:
- 5.4, 7.8, 10.9, 11.0, 12.4, 14.4, 15.5, 16.4, 16.7, 17.3, 18.3, and 19.7, wherein the XRPD is obtained using Cu K radiation and each of the 2-theta (°) values has an acceptable deviation of ±0.2°, or an XRPD pattern comprising at least three of the following d-spacing (Å) values:
- 16.2, 11.4, 8.1, 7.1, 6.1, 5.7, 5.4, 5.3, 5.1, 4.9, and 4.5.
A crystalline form of 3α,7α,11β-trihydroxy-6α-ethyl-5β-cholan-24-oic acid, wherein the crystalline form exhibits at least one of:
- an XRPD pattern comprising at least three of the following 2-theta (°) values:
- 4.4, 5.5, 6.0, 7.3, 8.5, 8.9, 9.5, 10.3, 10.7, 11.4, 12.2, 12.6, 14.1, 14.8, 16.5, 17.1, 17.6, 18.1, 18.7, 19.1, 19.3, 19.5, 20.0, 20.5, 20.9, 21.2, 21.9, 22.6, 23.3, 24.3, and 25.2, wherein the XRPD is obtained using Cu K radiation and each of the 2-theta (°) values has an acceptable deviation of ±0.2°;
- or
- an XRPD pattern comprising at least three of the following d-spacing (Å) values:
- 19.9, 16.2, 14.7, 12.1, 10.4, 9.9, 9.4, 8.6, 8.2, 7.8, 7.2, 7.0, 6.3, 6.0, 5.4, 5.2, 5.0, 4.9, 4.8, 4.6, 4.5, 4.4, 4.3, 4.2, 4.1, 3.9, 3.8, 3.7, and 3.5;
- or
- an XRPD pattern comprising at least three of the following 2-theta (°) values:
- 5.8, 8.5, 9.1, 9.8, 10.4, 13.0, 15.0, 16.1, 17.5, 18.1, and 22.9, wherein the XRPD is obtained using Cu K radiation and each of the 2-theta (°) values has an acceptable deviation of ±0.2°;
- or
- an XRPD pattern comprising at least three of the following d-spacing (Å) values:
- 15.1, 10.4, 9.7, 9.0, 8.5, 6.8, 5.9, 5.5, 5.1, 4.9, and 3.9;
- or
- an XRPD pattern comprising at least three of the following 2-theta (°) values:
- 5.8, 6.2, 7.4, 9.5, 11.7, 12.4, 14.2, 14.5, 15.1, 15.6, 16.0, 17.0, 17.4, 18.2, 19.0, and 20.8, wherein the XRPD is obtained using Cu K radiation and each of the 2-theta (°) values has an acceptable deviation of ±0.2°;
- or
- an XRPD pattern comprising at least three of the following d-spacing (Å) values:
- 15.3, 14.2, 12.0, 9.3, 7.6, 7.1, 6.2, 6.1, 5.9, 5.7, 5.5, 5.2, 5.1, 4.9, 4.7, and 4.3.
14 more elements
Dependencies are inferred from the claim text.