Bodipy compound, and temperature-sensitive fluorescent sensor of cell organelles comprising same
AssigneesInstitute for Basic Science, Postech Academy-Industry Foundation, National University Corporation Kanazawa University
InventorsYoung-Tae CHANG, Xiao LIU, Arai SATOSHI, Yamazaki TAKERU
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Abstract
The present invention relates to a BODIPY compound, and a temperature-sensitive fluorescent sensor of cell organelles comprising same. A BODIPY compound according to one aspect can quickly detect minute temperature changes with high sensitivity and accurately target various cell organelles and has no cytotoxicity. That is, the BODIPY compound according to one aspect can visualize the temperature for each cell organelle and is expected to be useful as a temperature-sensitive fluorescent sensor of cell organelles.
Claims12
A compound represented by the following Chemical Formula 1:
- wherein
- R1 and R2 are independently of each other (C1-C7)alkyl;
- L1 is —NR3C(═O)—, —C(═O)NR4—, or —NR5S(═O)2—;
- R3 to R5 are independently of one another hydrogen, (C1-C7)alkyl, or (C6-C12)aryl;
- L2 is a single bond, (C1-C30)alkylene, or (C1-C30)heteroalkylene;
- —CH2— of the alkylene and the heteroalkylene of L2 may be replaced with one or two or more selected from —C(═O)— and —S(═O)2—;
- the alkylene and the heteroalkylene of L2 may be further substituted by a hydroxyl group;
- A is (C2-C30)alkyl, (C2-C30)alkenyl, (C6-C30)aryl, (C1-C7)alkyl(C6-C30)aryl, (C2-C30)heteroaryl, (C2-C30)heterocycloalkyl,
- L3 and L4 are independently of each other (C2-C30)alkenylene, (C6-C30)arylene, or (C2-C30)heteroarylene;
- Ar1 is (C6-C30)aryl, (C1-C7)alkoxy(C6-C30)aryl, (C2-C30)heteroaryl, (C3-C30)cycloalkyl, or (C2-C30)heterocycloalkyl;
- Ar2 is (C6-C30)aryl or (C2-C30)heteroaryl;
- R6 and R7 are independently of each other hydrogen, (C1-C20)alkyl, (C6-C20)aryl, or
- Ar3 is (C6-C30)arylene or (C2-C30)heteroarylene;
- and
- r and s are independently of each other an integer of 1 to 5.
Dependencies are inferred from the claim text.