Fused Ring Compound and Preparation Method Therefor and Use Thereof

A compound or a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate, N-oxide, isotopically-labeled substance, metabolite or prodrug thereof, wherein the compound has the following structure:

• wherein, R1 and R2 are each independently selected from the group consisting of hydrogen, —CN, halogen, —ORa, —NH2, —NH(C1-6 alkyl), —N(C1-6 alkyl)2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, 3- to 6-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;
• the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of —CN, halogen, —OH, —NH2, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, 3- to 6-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;
• R4 and R4′ are each independently selected from the group consisting of hydrogen, halogen, —OH, —NH2, C1-6 alkyl, halogenated C1-6 alkyl and C1-6 alkoxy, both R5 and R5′ are hydrogen;
• or, R4 and R4′, together with the carbon atom connecting R4 and R4′, form a carbon-carbon double bond or a 3- to 6-membered carbocyclic ring, and both R5 and R5′ are hydrogen;
• or, R4 and R5 are connected to form a bond, or R4 and R5, together with the carbon atom connecting R4 and R5, form a 3- to 6-membered carbocyclic ring, and R5′ and R4′ are each independently selected from the group consisting of hydrogen, halogen, —NH2, C1-6 alkyl, halogenated C1-6 alkyl and C1-6 alkoxy;
• R6 is hydrogen, C1-6 alkyl or
• R6′, R7 and R7′ are all hydrogen;
• or, R6′ and R7 are connected to form a bond, and R7′ is hydrogen;
• Ra is selected from the group consisting of H, C1-6 alkyl or C3-6 cycloalkyl;
• Ring A is selected from the group consisting of 3- to 6-membered cycloalkyl, C6-10 aryl, 5- to 10-membered heteroaryl, 3- to 6-membered heterocyclyl;
• R3 is selected from the group consisting of hydrogen, —CN, halogen, —ORa, —NH2, —NH(C1-6 alkyl), —N(C1-6 alkyl)2, C1-6 alkyl, C3-6 cycloalkyl, 3- to 6-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;
• the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of —CN, halogen, —OH, —NH2, C1-6 alkyl, C1-6 alkoxy, C3-6 cycloalkyl, 3- to 6-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl;
• X and Y are each independently selected from the group consisting of —CH2—, —CD2-,
• and —C(O)—;
• m is selected from 1 to 5, such as 1, 2, 3, 4 or 5;
• n is selected from 1 to 10, such as 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10;
• when n is 5 and Ring A is phenyl, R3 is not methoxy.