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US 2026/0274843 A1Published application
Salt and solid forms of a cdk inhibitor
AssigneeGenentech, Inc.
InventorsXiaotian ZHU, Wenge ZHONG, Hu HE, Zhilong HU, Xiaomei DONG, Meiting SHI, Ruiping WANG
Life of this patent
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Abstract
Various salt forms and free base of Compound (I) represented by the following formula are disclosed.
Claims38
Crystalline Form II of Compound (I):
- characterized by an X-ray powder diffraction pattern which comprises peaks at chosen from 4.7°, 5.0°, 8.4°, and 21.8°±0.2 in 2θ.
Crystalline Form I of Compound (I):
- characterized by an X-ray powder diffraction pattern which comprises peaks at chosen from 6.8°, 18.4°, 21.4°, and 24.1°±0.2 in 2θ.
Crystalline Form III of Compound (I):
- characterized by an X-ray powder diffraction pattern which comprises peaks at chosen from 5.7°, 7.4°, 10.5°, 14.2°, and 20.5°±0.2 in 2θ.
Crystalline Form IV of Compound (I):
- characterized by an X-ray powder diffraction pattern which comprises peaks at chosen from 3.8°, 5.4°, and 15.8°±0.2 in 2θ.
Crystalline Form V of Compound (I):
- characterized by an X-ray powder diffraction pattern which comprises peaks at chosen from 8.8°, 11.1°, 20.2°, and 23.7°±0.2 in 2θ.
Crystalline Form VI of Compound (I):
- characterized by an X-ray powder diffraction pattern which comprises peaks at chosen from 5.6°, 9.9°, 13.7°, and 19.3°±0.2 in 2θ.
Crystalline Form VII of Compound (I):
- characterized by an X-ray powder diffraction pattern which comprises peaks at chosen from 5.3°, 5.6°, and 10.2°±0.2 in 2θ.
Crystalline Form I of maleate salt of Compound (I) represented by the following Formula:
- wherein the molar ratio between Compound (I) and maleic acid is 1:1, characterized by an X-ray powder diffraction pattern which comprises peaks at chosen from 5.7°, 9.3°, 10.3°, 13.9°, and 20.7°±0.2 in 2θ.
Crystalline Form I of tosylate salt of Compound (I) represented by the following Formula:
- wherein the molar ratio between Compound (I) and p-toluenesulfonic acid is 1:1, characterized by an X-ray powder diffraction pattern which comprises peaks at chosen from 9.5°, 11.0°, 14.1°, 21.4°, and 21.9°±0.2 in 2θ.
Dependencies are inferred from the claim text.