A3 adenosine receptor positive allosteric modulators

A compound of formula (I), a pharmaceutically acceptable salt thereof, or a stereoisomer thereof,

• wherein
• R1 is selected from the group consisting of alkyl, cycloalkyl, bicycloalkyl, tricycloalkyl, alkenyl, cycloalkenyl, bicycloalkenyl, tricycloalkenyl, cycloalkoxyalkyl, hydroxycycloalkyl, and cycloalkylcarbonyl, each of which is optionally deuterated, or optionally halogenated;
• and
• R2 is absent, halo, dihalo, trihalo, SF5, or a substituent selected from the following groups, each of which is optionally deuterated:
• alkylenyl, alkylaminocarbonyl, alkenyl, alkylamino carbonyl alkenyl, hetero bicyclylamino alkyl, carbonyl alkenyl, alkynyl, alkylaminoalkyl alkynyl, heterocyclylaminoalkyl alkynyl, heterocyclyloxy alkynyl, alkylaminocarbonylalkenyl, alkylamino iminoalkenyl, halo thiophenyl alkenyl, oxadizolylalkenyl, imidazolylaryl alkynyl, trialkoxyarylalkenyl, dioxyalrylalkenyl, monoalkoxyarylalkenyl, trifluoromethoxyarylalkenyl, trialkyl tin, and combinations thereof, wherein more than one R2 group can be present on the phenyl ring, and wherein each of the R2 group, other than halo, dihalo, trihalo, and SF5, is optionally deuterated and/or halogenated;
• R3 is hydrogen, deuterium, and/or halogen;
• R4 is hydrogen or alkyl;
• R5 is absent, halo, or a substituent selected from the group consisting of alkoxycarbonyl, which is optionally deuterated, amino, alkylamino, dialkylamino, trialkylamino, tetraalkylammonio, Boc-amino, guanidino, heterocyclylamino, hetero bicyclylamino, alkylamino imino, SF5, halo thiophenyl, oxadizolyl, imidazolylaryl, trialkoxyaryl, dioxyaryl, monoalkoxyaryl, trifluoromethoxyaryl, trialkyl tin, and combinations thereof, each of which is optionally be substituted with a reporter group, linked through an amine, amide, triazole, sulfonamide, urea, or thiourea group,
• X is O, S, or NR, wherein R is H or alkyl;
• and
• Y1 and Y2 are independently N or NH, O, or S;
• wherein the alkyl group is C1-C12 linear or branched alkyl, the cycloalkyl group is C3-C10 cycloalkyl group, the cyclic group of the bi- or tri-cycloalkyl is 3-10 membered, the alkenyl group is C2-C12 linear or branched alkenyl group, the cycloalkenyl group is 3-10 membered cyclic alkenyl group, the bicycloalkenyl and the tricycloalkenyl groups have 4 to 10 membered cycloalkenyl rings, the cycloalkoxyalkyl group is a C3-C10 cycloalkoxy C1-C12 linear or branched cycloalkyl group, the hydroxycycloalkyl group includes a hydroxyl group on a C3-C10 cycloalkyl group, and the cycloalkylcarbonyl group includes a C3-C10 cycloalkyl group.