New e3 ubiquitin ligase ligand, protein degradation agent and use thereof

A compound of Formula (I)

• or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof,
• wherein PBM represents a protein-binding moiety capable of binding to a target protein, and is covalently linked to ULM through LIN;
• ULM represents a ligand moiety capable of binding to an E3 ubiquitin ligase, and represents the structure of the following Formula (ULM):
• wherein A represents N or CH;
• Ra1, Ra2, Ra3, and Ra4 are the same or different and independently represent hydrogen, deuterium, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkoxy, or halogenated C1-6 alkoxy;
• ring W1 represents arylene or heteroarylene, wherein said ring W1 is optionally substituted with m Ra5, with each Ra5 being the same or different and independently representing halogen, hydroxy, mercapto, nitro, amino, cyano, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkoxy, halogenated C1-6 alkoxy, C2-6 alkenyl or C2-6 alkynyl;
• m represents an integer of 0, 1, 2, 3, or 4;
• X represents a bond or —Rb1—N(Ra6)—Rb2—, where Ra6 represents hydrogen or C1-6 alkyl, and Rbi and Rb2 each independently represent optionally substituted C0-2 alkylene;
• LIN is a linker moiety, representing a bond, optionally substituted methylene, or optionally substituted linear or branched C2-15 alkylene, wherein one or more groups selected from Ra, Rb, and any combination thereof are optionally inserted between one or more pairs of adjacent carbon atoms in the backbone carbon chain of the linear or branched C2-15 alkylene group;
• wherein each Ra is independently selected from the group consisting of O, C(O), OC(O), S, S(O), S(O)2, S(O)2N(Ra7), N(Ra7)S(O)2, C(O)N(Ra7), N(Ra7)C(O), N(Ra7), and N(Ra7)C(O)N(Ra7), where each Ra7 independently represents H or C1-3 alkyl, and in case that two or more groups Ra are inserted into the backbone carbon chain of the linear or branched C2-15 alkylene group, the two or more groups Ra are not directly connected to each other;
• and wherein each Rb is independently selected from the group consisting of optionally substituted cycloalkylene, optionally substituted arylene, optionally substituted heterocyclylene, optionally substituted heteroarylene, alkynylene, alkenylene, or any combination thereof.