Heterocycloalkyl beta-hydroxy alkyl amines for use in the treatment of hyperglycaemia and disorders characterised by hyperglycaemia

A compound of formula I

• or a pharmaceutically acceptable salt thereof, wherein:
• each of Q1 to Q5 independently represent carbon, a heteroatom or a direct bond such that the ring comprising Q1 to Q5 represents:
• phenyl optionally substituted with one or more Y1, or
• a 5- or 6-membered heteroaryl optionally substituted with one or more Y2;
• each Y1 independently represents halo, Ra1, —CN, —N3, —NRb1Rc1, or —ORd1;
• each Y2 independently represent halo, Ra2, —CN, —N3, —NRb2Rc2, or —ORd2;
• ring A represents a 4- to 7-membered heterocycloalkyl, comprising one or two heteroatoms selected from N and O;
• when present on a carbon atom of ring A, each Z independently represents halo, Ra3, CN, —N3, —N(Rb3)Rc3, —ORd3, —S(O)pRe3, —S(O)gN(Rf3)Rg3, —N(Rh3)S(O)tRi3, or ═O;
• when present on a nitrogen atom of ring A, each Z independently represents Ra3, —S(O)pRe3 or —S(O)qN(Rf3)Rg3;
• each Ra1, Ra2, Ra3, Re3 and Ri3 represents C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl each optionally substituted by one or more groups independently selected from halo and G1;
• each Rb1, Rb2, Rb3, Rc1, Rc2, Rc3, Rd1, Rd2, Rd3, Rf3, Rg3 and Rh3 independently represents H, or
• C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl each optionally substituted by one or more groups independently selected from halo and G2;
• or alternatively any of Rb1 and Rc1, Rb2 and Rc2, Rb3 and Rc3, and/or Rf3 and Rg3 may be linked together to form, together with the nitrogen atom to which they are attached, a 4- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ═O;
• each G1 and G2 independently represents Ra4, —CN, —N3, —N(Rb4)Rc4, —ORd4, —S(O)pRe4, —S(O)gN(Rf4)Rg4, or ═O;
• each Ra4 independently represents phenyl or 5- or 6-membered heteroaryl, each optionally substituted by one or more group selected halo, Ra5, —CN, —N3, —N(Rb5)Rc5, —ORd5, —S(O)pRe5, —S(O)gN(Rf5)Rg5, or —N(Rh5)S(O)tRi5;
• each Rb4, Rc4, Rd4, Rf4 and Rg4 independently represents H, or C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl optionally substituted by one or more halo or —CN;
• each Re4 independently represents C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl each optionally substituted by one or more halo or —CN;
• or alternatively any of Rb4 and Rc4 and/or Rf4 and Rg4 may be linked together to form, together with the nitrogen atom to which they are attached, a 4- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ═O;
• each Ra5, Re5, and Ri5 independently represents C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl each optionally substituted by one or more groups independently selected from from halo, C1-3 alkyl optionally substituted by one or more halo, and ═O;
• each Rb5, Rc5, Rd5, Rf5, Rg5 and Rh5 independently represents
• H, or
• C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl each optionally substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ═O;
• or alternatively any of Rb5 and Rc5, and/or Rf5 and Rg5 may be linked together to form, together with the nitrogen atom to which they are attached, a 4- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ═O;
• each p independently represents 0, 1 or 2;
• each q independently represents 1 or 2;
• each t independently represents 1 or 2;
• m represents 0 to 3;
• n represents 0 to 2;
• and
• r represents 0 to 6.