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US 2026/0274807 A1Published application
Err modulators
AssigneeUniversity of Health Sciences & Pharmacy in St. Louis
InventorsBahaa ELGENDY, Lamees Shamseldin HEGAZY, Thomas Patrick BURRIS
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Abstract
In one aspect, the present disclosure describes compounds which may be used to modulate the activity of an estrogen receptor-related orphan receptor (EER). Also described are pharmaceutical formulations, methods of synthesis and uses thereof.
Claims13
A method of modulating the activity of an estrogen related receptor comprising contacting the estrogen related receptor with a compound of the formula:
- wherein:
- X1 is O or S;
- A is C1-6 alkyl-aryl or C6 aryl;
- B is C1-6 alkyl, C6-10 cycloalkyl, C1-6 alkyl-C6-10 aryl, SC(O)-aryl, C6-10 aryl, 5-10 membered heteroaryl, or N(H)C(O)-aryl;
- R1 is H, halo, OH, N(R3)2, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C(O)C1-6 alkoxy, or B(OH)2;
- R2 is H, halo, N(R3)2, N(R4)2, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C(O)C1-6 alkoxy, C(O)OH, N(H)C(O)—C3-6 cycloalkyl, or aryl;
- R3 is H or O;
- R4 is O or C1-6 alkyl;
- m is 0, 1, or 2;
- and
- n is 0, 1, or 2;
- or a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.