Manifolds, systems and methods for conducting biological studies under flow
Assignee3D Systems, Inc.
InventorsBagrat GRIGORYAN, Jordan MILLER, Selene ALIKAH, Matthew GELBER, Faraz JIVAN, Andres RUIZ, Jacob SNOOK
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Abstract
Some embodiments of the disclosure disclose manifolds, microfluidic systems and methods that provide control over fluid flow distribution to an array of bio-scaffolds contained within the manifolds. In some embodiments, multiple perfusates may be injected into the manifold via multiple inlets where the manifold contains a bio-assembly with a substrate having a bio-scaffold disposed thereon. Biological investigations of the perfusates may then be conducted in the vascular components and chambers of the bio-scaffold.
Claims21
1-108. (canceled)
A manifold, comprising:
- a plate having one or more partitions, a first partition of the one or more partitions including:
- a first recess shaped and sized to receive a first bio-assembly having a first bio-assembly inlet, a first bio-assembly outlet and a first bio-scaffold that is disposed on a substrate,
- a bio-scaffold inlet of the first bio-scaffold being in fluid communication with the first bio-assembly inlet and a bio-scaffold outlet of the first bio-scaffold being in fluid communication with the first bio-assembly outlet;
- and
- a bio-scaffold access channel coupled to the bio-assembly outlet of the first bio-assembly and configured to transport fluids between an interior of the first bio-assembly and outside the first bio-assembly via the bio-assembly outlet.
Dependencies are inferred from the claim text.