Methods For Inhibiting Neuronal Degeneration To Preserve Residual Functionality And Enhance Axonal Fusion
OwnerJustin C. Burrell, D. Kacy Cullen +3inventors
InventorsJustin C. Burrell, D. Kacy Cullen, Christopher Cardozo, Carlos Toro Chacon, Tomisin Latona
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Abstract
Disclosed herein are methods of inhibiting sterile alpha and TIR motif-containing protein 1 (SARM1) NADase activity in an axon. The methods can also be used to reduce or delay degeneration in an axon, treat or prevent degeneration of an injured axon, enhance fusion of one or more severed axons, and delay degeneration of one or more fused axons, as well as treat a neurological nerve injury or a neurodegenerative disease in a subject in need thereof using a SARM 1 inhibitor.
Claims28
A method of inhibiting sterile alpha and TIR motif-containing protein 1 (SARM1) NADase activity in an axon, the method comprising:
- contacting the axon with an effective amount of a SARM1 inhibitor, thereby inhibiting SARM1 NADase activity in the axon.
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A method of treating or preventing degeneration of an injured axon, the method comprising:
- contacting a neural tissue comprising the injured axon ex vivo with an effective amount of a sterile alpha and TIR motif-containing protein 1 (SARM1) inhibitor, thereby treating or preventing degeneration in the injured axon.
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A method of enhancing fusion of one or more severed axons, the method comprising:
- (a) contacting ex vivo a neural tissue comprising the one or more severed axons with an effective amount of a sterile alpha and TIR motif-containing protein 1 (SARM1) inhibitor;
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- (b) contacting ex vivo the neural tissue comprising the two or more severed axons in (a) with an effective amount of a fusogen,
- wherein the contacting in (a) is prior to or concurrent with the contacting of (b), thereby enhancing the fusion of the one or more severed axons.
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Dependencies are inferred from the claim text.