Cell graft delivered in a delivery system and use thereof in regenerative medicine
AssigneeChina Medical University
InventorsShih-Chieh HUNG, Chun-Te HO
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Abstract
The present invention relates to a cell graft delivery system comprising a cell graft bound to a novel bifunctional peptide (BiFP), with tissue targeting function and cell differentiation instruction function, for delivering the cell graft to a target tissue. The bifunctional peptide (BiFP) of present invention is constructed with a peptide comprising collagen XII-targeting sequence mediating the tissue targeting function and an integrin/DDR binding motif sequence mediating the cell binding and cell differentiation instruction function.
Claims24
A cell graft delivery system, comprising a cell graft and a bifunctional peptide (BiFP) delivering the cell graft to a target tissue, wherein the cell graft is bound to the BiFP which is consisted of a tissue-targeting sequence and a cell-binding motif sequence flanked by GPO repeats.
A method for treating a disease involving collagen XII expression, comprising administering a subject in need thereof with a therapeutically effective amount of a cell graft delivered with a bifunctional peptide (BiFP), wherein the bifunctional peptide is consisted of a tissue-targeting sequence and a cell-binding motif sequence flanked by GPO repeats.
A cell graft composition for regenerative medicine, comprising a cell graft delivered with a bifunctional peptide (BiFP), wherein the bifunctional peptide is consisted of a tissue-targeting sequence and a cell-binding motif sequence flanked by GPO repeats.
Dependencies are inferred from the claim text.