Biopolymer scaffolds and methods for production or use thereof
AssigneeBionova Medical, Inc.
InventorScott P. NOEL
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Abstract
Methods for the manufacture of porous biopolymer scaffolds containing a first biopolymer in combination with chondroitin sulfate and/or hyaluronic acid, compositions made by such methods, and use of the biopolymer scaffolds in dermal regeneration. Non-limiting examples of first biopolymers include alginate, chitosan, collagen, cellulose, gelatin, starch, and various combinations thereof.
Claims30
A biopolymer scaffold comprising chondroitin sulfate and/or hyaluronic acid and chitosan, collagen, and/or alginate, wherein if the biopolymer scaffold contains chondroitin sulfate and not hyaluronic acid, then the biopolymer scaffold does not contain collagen.
A method for producing a biopolymer scaffold, the method comprising:
- (a) dissolving chondroitin sulfate and/or hyaluronic acid in an aqueous solution at about neutral pH;
- (b) adding to the solution chitosan, collagen, and/or alginate and a combined volumetric percent of about 0.25% to about 2.0% of lactate and acetate;
- (c) lyophilizing the aqueous solution of (b) to produce a biopolymer scaffold;
- (d) adjusting the pH of the biopolymer scaffold to a pH between about 6.0 to about 8.0;
- and
- (e) lyophilizing the biopolymer scaffold of (d) to produce a biopolymer scaffold.
Dependencies are inferred from the claim text.