Combination for and method of suppressing sarcoma or carcinoma malignancies
AssigneeIsm Biosciences LLC
InventorsMax Temnik, Victor Gurin, Sergey Gurin
Life of this patent
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Abstract
A method for treating carcinoma and sarcoma tumors includes administration of a composition including 64Zne(Asp) or 63Cue(Asp) in a therapeutically effective amount. The method may be used once a day or more than once a day. Other identified amino acids may be bound to 64Zne and 63Cue instead of L-Aspartate (Asp), provided that such amino acids are enriched for the L-enantiomer to at least 90%. The composition is suitable for a parenteral injection or infusion. The method may be used for suppressing growth of carcinoma and sarcoma, including preventing the development of metastases.
Claims13
A method of suppressing tumor growth of carcinoma or sarcoma malignancy in a patient in need thereof including administering a pharmaceutical composition to said patient, the composition including a therapeutically effective amount of 64Zne(Asp), wherein from 3.8 μg/kg patient weight/day to 75 mg/kg patient weight/day of 64Zne(Asp) is administered to said patient intratumorally or intravenously and wherein the 64Zne is at least 99% 64Zn, wherein the composition comprises 2 molecules of aspartic acid per each atom of 64Zne.
(canceled)
10-20. (canceled)
A method of suppressing tumor growth of carcinoma or sarcoma malignancy in a patient in need thereof including administering a pharmaceutical composition to said patient, the composition including a therapeutically effective amount of 64Zne(Asp), wherein from 3.8 μg/kg patient weight/day to 75 mg/kg patient weight/day of 64Zne(Asp) is administered to said patient intratumorally or intravenously and wherein the 64Zne is at least 99% 64Zn, wherein:
- the composition comprises 2 molecules of aspartic acid per each atom of 64Zne;
- the 64Zne(Asp) composition is in an aqueous solution;
- the composition includes deuterium-depleted water.
Dependencies are inferred from the claim text.