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US 2026/0273080 A2Published application
Bioactive Conjugate, Preparation Method Therefor and Use Thereof
AssigneeBeOne Medicines I GmbH
InventorsCharng-Sheng Tsai, Mei-Hsuan Tsai, Bing Li, Liming Wu
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Abstract
The present disclosure provides antibody drug conjugate platforms comprising a conjugator assembly component, and antibody drug conjugates comprising platform-derived linker-payloads and antibodies or antigen-binding fragments thereof. In some embodiments, an antibody drug conjugate is of the following formula or a pharmaceutically acceptable salt, tautomer, solvate, or stereoisomer thereof, wherein values for the variables (e.g., BA, U, V, A, a′, W, w′, Y, y′, PA, x) are as described herein.
Claims91
A compound of Formula (I):
- or a pharmaceutically acceptable salt, tautomer, solvate, or stereoisomer thereof, wherein:
- BA is a binding agent selected from a humanized, chimeric, or human antibody or an antigen binding fragment thereof;
- U is arylene, heteroarylene, or a bond;
- V is a bond or —C≡C—(CH2)n—;
- n is an integer between 0 and 10;
- A is a Stretcher unit residue;
- subscript a′ is 0 or 1;
- W is a Cleavable unit;
- subscript w′ is 0 or 1;
- Y is a Spacer unit;
- subscript y′ is 0 or 1;
- PA is a payload residue;
- and
- subscript x is from 1 to 15.
11 more elements
A compound of Formula (II):
- or a pharmaceutically acceptable salt, tautomer, solvate, or stereoisomer thereof, wherein:
- U is arylene, heteroarylene, or a bond;
- V is a bond or —C≡C—(CH2)n—;
- n is an integer between 0 and 10;
- A is a Stretcher unit residue;
- subscript a′ is 0 or 1;
- W is a Cleavable unit;
- subscript w′ is 0 or 1;
- Y is a Spacer unit;
- subscript y′ is 0 or 1;
- and
- PA is a payload residue.
9 more elements
A compound of Formula (III):
- or a pharmaceutically acceptable salt, tautomer, solvate, or stereoisomer thereof, wherein:
- U is arylene, heteroarylene, or a bond;
- V is a bond or —C≡C—(CH2)n—;
- n is an integer between 0 and 10;
- A is a Stretcher unit;
- and
- subscript a′ is 0 or 1.
4 more elements
Dependencies are inferred from the claim text.