Methods of evading immune rejection
OwnerOmid VEISEH, Amanda NASH +3inventors
InventorsOmid VEISEH, Amanda NASH, Boram KIM, Dilrasbonu VOHIDOVA, Samantha FLEURY
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Abstract
The present disclosure is directed to methods, compositions and devices capable of avoiding foreign body responses to implanted material. This technology utilizes polymer encapsulated engineered cells that produce natural, cell-generated cytokines to elicit a tailored immune response to implanted materials for applications in diabetes, immune tolerance, and organ transplantation.
Claims15
An implantable construct comprising an engineered cell expressing one or more cytokines, such as interleukin-12 (IL-12), interleukin-10 (IL-10) and/or interleukin-35 (IL-35), such as heterodimeric IL-12.
A method of making or manufacturing an implantable construct comprising introducing into an implantable construct an engineered cell expressing one or more cytokines, such as interleukin-12 (IL-12), interleukin-10 (IL-10) and/or interleukin-35 (IL-35).
Dependencies are inferred from the claim text.