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US 2026/0273058 A1Published application
In vivo daric
AssigneeKelonia Therapeutics, Inc.
InventorsKevin M. Friedman, Michael J. McDonald
Life of this patent
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Abstract
The present disclosure provides compositions and methods effective for transducing cells in vivo with a recombinant retrovirus comprising a polynucleotide encoding a dimerizing agent regulated immunoreceptor complex (DARIC).
Claims65
A recombinant virus comprising:
- (a) a viral envelope comprising (i) one or more mutated viral envelope glycoproteins that retain fusogenic activity and lack cognate receptor binding activity and (ii) one or more non-viral membrane-bound tropism polypeptides, and
- (b) a recombinant retroviral vector comprising a polynucleotide encoding a promoter operably linked to a polynucleotide encoding a DARIC signaling component and a DARIC binding component.
Dependencies are inferred from the claim text.