Antigen-specific physiologic dendritic cells for vaccination
AssigneesYale University, Transimmune AG, Emory University
InventorsOlga SOBOLEV, Richard EDELSON, Aaron VASSALL, Kazuki TATSUNO, Philip J. SANTANGELO, Douglas HANLON
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Abstract
This invention relates to compositions comprising physiologic dendritic cells and at least one miRNA. The invention further relates to compositions comprising physiologic dendritic cells and at least one mRNA for use in vaccination.
Claims22
A vaccine composition comprising a pharmaceutically effective amount of physiological DCs (phDCs) and at least one mRNA, which comprises a coding sequence encoding for at least one antigenic protein.
The vaccine composition according to any one of 14, wherein more than 30%, 40%, 50%, 60%, 70%, 80%, or 90% of the mRNA is not incorporated into the phDCs.
Dependencies are inferred from the claim text.