Immunogenic trimers
AssigneesInternational AIDS Vaccine Initiative, The Scripps Research Institute
InventorsJon Steichen, Dan Kulp, Xiaozhen Hu, Sergey Menis, William Schief, Sebastian Raemisch
Life of this patent
Estimating the term…
Abstract
The invention relates to PGT121-germline-targeting designs, trimer stabilization designs, combinations of those two, trimers designed with modified surfaces helpful for immunization regimens, other trimer modifications and on development of trimer nanoparticles and methods of making and using the same.
Claims20
(canceled)
An isolated mRNA comprising a translatable region encoding a non-naturally occurring protein and at least one nucleoside modification, wherein the non-naturally occurring protein comprises an immunogen comprising a gp120 or gp140 trimer comprising one or more stabilizing mutations, and wherein the non-naturally occurring protein comprises an amino acid sequence having at least 90% identity to an amino acid sequence selected from SEQ ID NO:
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Dependencies are inferred from the claim text.