Immunogenic compositions against influenza and rsv

A composition comprising

• a. (i) a first ribonucleic acid (RNA) polynucleotide comprising an open reading frame encoding a first antigen, said antigen comprising at least one influenza virus hemagglutinin (HA) polypeptide or an immunogenic fragment thereof, wherein the first RNA polynucleotide is formulated in a lipid nanoparticle (LNP);
• and
• (ii) a first RSV F protein trimer in the prefusion conformation;
• and/or
• b. further comprising (iii) a second RNA polynucleotide comprising an open reading frame encoding a second influenza virus hemagglutinin (HA) polypeptide or an immunogenic fragment thereof;
• (iv) a third RNA polynucleotide comprising an open reading frame encoding a third influenza virus hemagglutinin (HA) polypeptide or an immunogenic fragment thereof;
• and/or
• c. further comprising a fourth RNA polynucleotide comprising an open reading frame encodinq a fourth antigen, said antigen comprising at least one influenza virus antigenic polypeptide or an immunogenic fragment thereof.