Compositions and methods for preventing, controlling and diagnosing mycobacterial infections
AssigneeUniversity of Saskatchewan
InventorsAntonio Facciuolo, Philip Griebel, Volker Gerdts, Andrew Potter, Neil Rawlyk, Jeffrey Chen, Elodie Pastural, Manjeet Bains, Michael Trimble, Amy Lee, Robert Hancock
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Abstract
Mycobacterial antigens, such as MAP and M. bovis antigens, are described. The antigens can be used in subunit compositions to elicit immune responses in order to prevent and/or control mycobacterial infections, as well as in diagnostics in order to detect mammals infected with mycobacteria.
Claims20
An immunogenic, subunit composition comprising a pharmaceutically acceptable excipient and at least one isolated, mycobacterial antigen selected from (a) a Mycobacterium avium subspecies paratuberculosis (MAP) antigen, or an ortholog thereof, wherein the MAP antigen or ortholog is from Tables 1, 2, 3, 4, or 5;
- (b) a Mycobacterium bovis (M. bovis) antigen from Tables 2 or 5;
- an immunogenic fragment of (a) or (b);
- an immunogenic variant of (a) or (b);
- or the corresponding antigen from another mycobacterial strain or isolate, with the proviso that the selected mycobacterial antigen is not MAP 2785c or MAP 1981c.
A method of detecting mycobacterial antibodies in a biological sample comprising:
- (a) providing a biological sample;
- (b) reacting said biological sample with one or more mycobacterial antigens from Tables 1, 2, 3, 4 or 5, an immunogenic fragment or variant thereof, or the corresponding antigen from another mycobacterial strain or isolate, under conditions which allow mycobacterial antibodies, when present in the biological sample, to bind to said one or more antigens to form an antibody/antigen complex;
- and
- (c) detecting the presence or absence of said complex,
- thereby detecting the presence or absence of mycobacterial antibodies in said sample.
Dependencies are inferred from the claim text.