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US 2026/0272995 A1Published application
Intracellular Delivery of Therapeutic Cargos and Viral RNAS by Engineered Salmonella
AssigneeThe Trustees of Columbia University in the City of New York
InventorsTal DANINO, Jonathan PABON, Zakary SINGER, Charles M. RICE
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Abstract
Salmonella typhimurium comprising a first heterologous nucleic acid encoding a first polypeptide that causes bacterial lysis, a second heterologous nucleic acid encoding a second polypeptide that causes vacuolar lysis, and a third heterologous nucleic acid encoding a virus.
Claims20
An engineered Salmonella typhimurium bacterium, comprising:
- (a) a lysis circuit comprising a first heterologous nucleic acid encoding a first polypeptide that causes bacterial lysis and a second heterologous nucleic acid encoding a second polypeptide that causes vacuolar lysis;
- and
- (b) a third heterologous nucleic acid encoding a virus.
A method of treating a tumor in a subject comprising administering a therapeutically effective amount of engineered Salmonella typhimurium bacteria, wherein the bacteria comprise:
- (a) a lysis circuit comprising a first heterologous nucleic acid encoding a first polypeptide that causes bacterial lysis and a second heterologous nucleic acid encoding a second polypeptide that causes vacuolar lysis;
- and
- (b) a third heterologous nucleic acid encoding a virus.
Dependencies are inferred from the claim text.