Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
AssigneeCedars-Sinai Medical Center
InventorsEduardo Marban, Mark Amin Aminzadeh
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Abstract
Described herein are compositions and techniques related to generation and therapeutic application of cardiosphere-derived cells (CDCs) and CDC-derived exosomes. These cells and their secreted vesicles contain a unique milieu of biological factors, including cytokines, growth factors, transcription factors, nucleic acids including non-coding nucleic acids such as microRNAs, that serve to initiate and promote many therapeutic effects. Exosomes and their “cargo” contents, such as microRNAs can favorably modulate apoptosis, inflammation and fibrosis in the injured heart. Thus, CDC-derived exosomes represent a novel “cellfree” therapeutic candidate for tissue repair.
Claims20
A method of forestalling the progression of dilated cardiomyopathy associated with muscular dystrophy, comprising:
- selecting a subject having muscular dystrophy who is in need of treatment;
- obtaining a composition comprising cardiosphere-derived cells;
- and
- administering the composition comprising cardiosphere-derived cells to the subject;
- wherein composition comprising cardiosphere-derived cells comprises a therapeutic amount of cardiosphere-derived cells;
- and
- wherein administration of the composition comprising cardiosphere-derived cells to the subject treats the subject.
A method of forestalling the progression of dilated cardiomyopathy associated with muscular dystrophy, comprising:
- selecting a subject having muscular dystrophy who is in need of treatment;
- obtaining a composition comprising exosomes obtained from cardiosphere-derived cells;
- and
- administering the composition comprising exosomes obtained from cardiosphere-derived cells to the subject;
- wherein composition comprising exosomes obtained from cardiosphere-derived cells comprises a therapeutic amount of exosomes obtained from cardiosphere-derived cells;
- and
- wherein administration of the composition comprising exosomes obtained from cardiosphere-derived cells to the subject treats the subject.
A method of forestalling the progression of dilated cardiomyopathy associated with muscular dystrophy, comprising:
- selecting a subject having muscular dystrophy who is in need of treatment;
- and
- administering a therapeutic amount of miR-146a to the subject;
- wherein administration of the therapeutic amount of miR-146a to the subject treats the subject.
Dependencies are inferred from the claim text.