Selenoglycoside decoys of glycosylation for anti-inflammatory and antiviral pharmaceuticals

Abstract

In one aspect, the disclosure relates to In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to acetylated glycosides comprising at least one O, S, or Se atom external to the glycoside ring, wherein the O, S, or Se is bonded to a moiety selected from C1-C20 linear or branched alkyl, alkenyl, aryl, alkylaryl, or arylalkyl. Also disclosed are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating or preventing viral diseases and their symptoms in a subject using the same. In one aspect, the glycosides target host cell glycan decoration of viral proteins and do not cause the viruses to mutate. In another aspect, the glycosides and pharmaceutical compositions comprising the same can be applied topically and thereby do not cause systemic side effects in the subject.

Dependencies are inferred from the claim text.