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US 2026/0272888 A1Published application
Wound treatment composition
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsTakako NAKASHIMA, Naoya ARICHIKA, Hidetaka HIYAMA, Takakuni MATSUDA, Kengo MATSUMOTO, Daisuke YAMASHITA
Life of this patent
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Abstract
The present disclosure provides a composition for a treatment for a wound, and the like. N-({2-[4-(difluoromethoxy)-3-(propan-2-yloxy)phenyl]-1,3-oxazol-4-yl}methyl)-2-ethoxybenzamide or its salt is useful as an active ingredient of a composition for a treatment for a wound.
Claims19
1:
- A method of treatment for wound, the method comprising:
- administering a composition comprising N-({2-[4-(difluoromethoxy)-3-(propan-2-yloxy)phenyl]-1,3-oxazol-4-yl}methyl)-2-ethoxybenzamide or its salt to a subject in need thereof,
- wherein the subject has a wound.
2:
- The method according to claim 1, wherein the wound is a skin wound and the method comprises:
- applying the composition to the skin wound of the subject.
3:
- The method according to claim 2, wherein the skin wound is a pressure ulcer, a skin ulcer, a burn, a laceration, an abrasion, a leg ulcer, a diabetic ulcer, a venous stasis ulcer, an ischemic (arterial) ulcer, a foot ulcer, a foot gangrene, or a radiation skin ulcer.
4:
- The method according to claim 2, wherein the skin wound is a pressure ulcer.
5:
- The method according to claim 1, wherein the composition is for promotion of epidermis formation.
6:
- The method according to claim 1, wherein the composition acts via a fibroblast.
7:
- The method according to claim 1, wherein the wound is a mucosal wound, and the method comprises:
- applying the composition to the mucosal wound of the subject.
8:
- The composition according to claim 7, wherein the mucosal wound is an oral mucosal wound or an ocular mucosal wound.
9:
- The method according to claim 8, wherein
- the mucosal wound is an oral mucosal wound, and
- the oral mucosal wound is an oral mucositis, a stomatitis, an oral ulcer, an oral erosion, a glossitis, or a cheilitis.
10:
- The method according to claim 8, wherein
- the mucosal wound is an ocular mucosal wound, and
- the ocular mucosal wound is a keratoconjunctival epithelial disorder, a corneal epithelial disorder, a corneal erosion, superficial punctate keratopathy, dry eye, a keratitis accompanied by a corneal wound, or conjunctivitis accompanied by a conjunctival wound.
11:
- The method according to claim 8, wherein
- the mucosal wound is an ocular mucosal wound, and
- the ocular mucosal wound is dry eye accompanied by a keratoconjunctival epithelial disorder.
12:
- The method according to claim 1, wherein the composition is a preparation for external use.
13:
- The method according to claim 12, wherein the preparation for external use is an ointment or a cream, and the method comprises:
- applying the composition to a skin wound of the subject.
14:
- The method according to claim 12, wherein the preparation for external use is an eye drop or an eye ointment, and the method comprises:
- applying the composition to an eye of the subject.
15:
- The method according to claim 12, wherein the preparation for external use is a mouthwash, an oral spray, or an oral ointment, and the method comprises:
- applying the composition to an oral cavity of the subject.
16:
- The method according to claim 12, wherein the preparation for external use contains N-({2-[4-(difluoromethoxy)-3-(propan-2-yloxy)phenyl]-1,3-oxazol-4-yl}methyl)-2-ethoxybenzamide or its salt in an amount of 0.1 to 10 mass % in terms of N-({2-[4-(difluoromethoxy)-3-(propan-2-yloxy)phenyl]-1,3-oxazol-4-yl}methyl)-2-ethoxybenzamide.
17:
- The method according to claim 12, wherein the method comprises:
- administering the composition 1 to 2 times a day.
18:
- The method according to claim 12, wherein the method comprises:
- administering the composition 1 to 4 times a day.
19:
- The method according to claim 1, wherein the composition is a wound dressing.