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AssigneesInstitute of Zoology, Chinese Academy of Sciences, Beijing Institute for Stem Cell and Regenerative Medicine
InventorsWei LI, Qi ZHOU, Zheng-Quan HE, Zongbao LU, Xuewei YUAN, Xin WANG, Shuai WANG, Liu WANG
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Provided is use of a retinoic acid receptor activator or a composition containing the retinoic acid receptor activator in preparing a drug or reagent for promoting the regeneration and repair capacity of tissues or complex structures or organs of mammals. The retinoic acid receptor activator comprises one or two or more of all-trans retinoic acid and a selective retinoic acid receptor y agonist. The regeneration and repair refer to promoting the regeneration of tissues or complex structures or organs after tissue or organ resection or damage.
Use of a retinoic acid receptor activator or a composition comprising the retinoic acid receptor activator in the promotion of regeneration and repair capacity of a tissue, complex structure or organ of a mammal or in the treatment of a disease related to regeneration and repair of a tissue, complex structure or organ of a mammal.
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A composition, wherein it comprises a protein synthesis inhibitor, and an all-trans retinoic acid and a BMP activator, preferably the protein synthesis inhibitor is Cycloheximide (CHX) or Narciclasine, and the BMP activator is BMP signaling agonist sb4.
A method for promoting regeneration and repair of a tissue, complex structure or organ of a mammal, comprising administering a retinoic acid receptor activator or a composition comprising the retinoic acid receptor activator to a subject in need thereof.
Dependencies are inferred from the claim text.