Tablet formulation comprising a glp-1 peptide and a delivery agent
AssigneeNovo Nordisk A/S
InventorsSimon Bjerregaard, Per Sauerberg, Flemming Seier Nielsen, Betty Lomstein Pedersen, Erik Skibsted
Life of this patent
Estimating the term…
Abstract
The present invention relates to solid compositions comprising a GLP-1 peptide and a delivery agent, such as SNAC, as well as uses thereof.
Claims13
A tablet comprising a granulate comprising:
- i) no more than 15% (w/w) GLP-1 peptide, and
- ii) at least 50%, 55%, or 60% (w/w) salt of N-(8-(2-hydroxybenzoyl)amino) caprylic acid (NAC).
A process for the preparation of a tablet comprising a granulate comprising i) no more than 15% (w/w) GLP-1 peptide, and ii) at least 50% (w/w) salt of NAC, said method further comprising the step of exerting a compression force when punching said tablet of a) at least 5 kN, such as 5-25 KN, at least 10 kN or at least 15 kN, and/or b) at least 4 kN/cm2, such as at least 6 kN/cm2 or at least 8 kN/cm2,
- wherein said process optionally comprises a pre-compression step.
Dependencies are inferred from the claim text.