Injectable gel composition

An injectable gel composition for controlled, short-term delivery of a fertility hormone to a subject, the injectable gel composition comprising:

• (a) 0.5–20% w/w high molecular weight hyaluronic acid having a molecular weight of 1000–1400 kDa;
• and
• (b) 0.5–20% w/w methylcellulose having a viscosity of 100–8000 cP,
• wherein the hyaluronic acid is non-crosslinked,
• wherein the hyaluronic acid and the methylcellulose form a physically assembled hydrated polymer matrix through reversible physical interactions and in an absence of added chemical crosslinking agents,
• wherein the injectable gel composition exhibits shear-responsive flow sufficient to permit injection through a needle or microneedle lumen and recovers mechanical cohesion upon cessation of shear,
• wherein the fertility hormone is present in unmodified form within the hydrated polymer matrix,
• wherein the hydrated polymer matrix retains the fertility hormone at an administration site,
• wherein the hydrated polymer matrix loses structural cohesion and disperses, dilutes, or loses structural integrity within 1–14 days following administration without formation of a covalently crosslinked polymer depot, and
• wherein sustained hormone delivery is achieved over hours to days without irreversible commitment to prolonged exposure.