Pulse stimulator for cell ablation and method thereof
AssigneeNational Taiwan University of Science and Technology
InventorsFu-Ming WANG, Zong-Yu YANG, Peng-Hui WANG
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Abstract
Provided is a pulse stimulator for cell ablation, including: a generator configured to deliver an electrical pulse to at least one electrode, the electrical pulse includes: a positive voltage, a negative voltage, or a combination thereof based on a resting membrane potential, or, a positive power, a negative power, or a combination thereof based on an extracellular membrane potential being 0 volt, in which the electrical pulse delivery frequency ranges from 0.001 Hz to less than 1 Hz to achieve non-thermal ablation of a plurality of cells in a target area.
Claims20
A pulse stimulator for cell ablation, comprising:
- a generator configured to deliver an electrical pulse to at least one electrode, the electrical pulse comprising:
- a positive voltage, a negative voltage, or a combination thereof based on a resting membrane potential;
- or
- a positive power, a negative power, or a combination thereof based on an extracellular membrane potential being 0 volt,
- wherein a delivery frequency of the electrical pulse comprises from 0.001 Hz to less than 1 Hz, and
- wherein the electrical pulse is configured to non-thermal ablate a plurality of cells in a target area.
A method for cell ablation, comprising:
- providing at least one electrode, the at least one electrode disposed on a plurality of cells in a target area;
- transmitting an electrical pulse to the at least one electrode;
- and
- ablating the plurality of cells in the target area, wherein the electrical pulse is configured to non-thermal ablate the plurality of cells in the target area,
- wherein the electrical pulse comprises:
- a positive voltage, a negative voltage, or a combination thereof based on a resting membrane potential;
- or
- a positive power, a negative power, or a combination thereof based on an extracellular membrane potential being 0 volt, and
- wherein a delivery frequency of the electrical pulse comprises from 0.001 Hz to less than 1 Hz.
Dependencies are inferred from the claim text.