Atraumatically formed tissue compositions, devices and methods of preparation and treatment
AssigneeTissueMill Technologies LLC
InventorsThomas Andrew Davenport, Paul Mulhauser, Gregory C. Guinan
Life of this patent
Estimating the term…
Abstract
A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.
Claims13
A device for processing tissue so as to maintain tissue viability comprising:
- a stationary cutting device and a movable cutting device supported in compressive engagement, said movable cutting device being movable with respect to said stationary cutting device to cut tissue therebetween, said stationary cutting device including breaches therethrough configured to atraumatically cut said tissue in combination with said movable cutting device, in a slicing action;
- an agitation device which causes repeated continuous recirculating flow of said fluid and tissue through said cutting devices, said agitation device capable of moving in concert with said movable cutting device and repeatedly recirculating said fluid and tissue through said cutting devices to atraumatically cut said tissues repeatedly, while maintaining said tissue viability;
- and
- wherein said agitation device includes an impeller movable with said movable cutting device in a rotational direction about an axis, said impeller shaped to include a leading portion adjacent said cutting devices for imparting an axial thrust and a terminal portion for imparting a radial thrust for causing fluid repeated recirculating flow through said cutting devices.
A device for processing tissue comprising:
- a stationary cutting device and a movable cutting device supported in compressive physical contact along a common shear plane, said movable cutting device being movable with respect said stationary cutting device to cut tissue therebetween;
- an agitation device supported within said aseptic container which causes repeated continuous recirculating flow of said fluid and tissue through said cutting devices, said agitation device capable of moving in concert with said movable cutting device and repeatedly recirculating said fluid and tissue through said cutting devices to atraumatically cut said tissue repeatedly, while maintaining said tissue viability.
A method for processing tissue into particulate form comprising:
- providing a stationary cutting device and movable cutting device in mutual compressive engagement;
- introducing fluid and tissue into said container;
- moving said movable cutting device with respect to said stationary cutting device to cut said tissue through breaches formed in the stationary cutting device to atraumatically cut said tissue in combination with said movable cutting device, in a slicing action;
- providing an impeller to continuously recirculate said fluid and said tissue through said cutting devices to repeatedly atraumatically cut said tissue into progressively smaller particulates, said impeller shaped to include a leading portion proximal to said cutting devices for imparting an axial thrust and a terminal portion distal to said cutting devices for imparting a radial thrust for causing said continuous recirculation through said devices for repeated cutting of said tissue.
Dependencies are inferred from the claim text.