Repositionable over-the-scope clip

A clipping system for treating tissue, comprising:

• a cap configured to be mounted over a distal end of an insertion device, the cap extending from a proximal end to a distal end and including a channel extending therethrough, the cap including a first cap member and a second cap member, wherein the first cap member is rotatable relative to the second cap member;
• a clip including a peripheral body including a first part rotatably coupled to a second part and a plurality of first flexible members coupled to the first part and a corresponding plurality of second flexible members that are coupled to the second part, each of the first flexible members being coupled to a corresponding one of the second flexible members to form an iris mechanism operating to alter a size of a central opening of the clip when the first and second parts are rotated relative to one another from a fully open configuration in which the central opening is a maximum size configured to receive target tissue therein and a fully closed configuration in which the central opening is a minimum size configured to clip target tissue received therein;
• a fist coupling member coupled between the first cap member and the first part of the clip;
• and
• a second coupling member coupled between the second cap member and the second part of the clip so that, upon rotation of the first cap member relative to the second cap member, the first part of the clip is rotated relative to the second part of the clip.

A method of clipping tissue, comprising:

• coupling to an endoscope a device including a cap having a first cap member and a second cap member and a clip coupled to the cap via first and second control members, the clip including a first part rotatably coupled to a second part and a plurality of first flexible members extending within the first part, each of the first flexible members having a first end coupled to the first part, the clip further including a corresponding plurality of second flexible members each of which includes a first end coupled to the second part, a second end of each of the first flexible members being coupled to a second end of a corresponding one of the second flexible members to form an iris mechanism;
• rotating the first and second parts of the clip relative to one another in a first direction via the first and second control members to open a central opening of the clip to a fully open configuration in which the central opening is a maximum size configured to receive target tissue therein;
• drawing tissue through the central opening of the clip into the cap;
• and
• rotating the first and second parts of the clip relative to one another in a second direction opposite the first direction to close the clip to clip the tissue extending through the central opening of the clip.