Transocular diagnostic device and method for parkinson’s disease caused by substantia nigra dopaminergic neurodegeneration

A transocular diagnostic device for Parkinson's disease caused by substantia nigra dopaminergic neurodegeneration, comprising:

• an optical vision device configured to provide an optical visual stimulation to an eye of a subject before and after a specific condition of increased dopamine levels in a body of the subject, and at the same time record a stimulation index S during the optical visual stimulation and send the stimulation index S to a signal processing device;
• a fundus blood flow detection device configured to detect and record fundus blood vessel and blood flow parameter change information before and after the specific condition of increased dopamine levels in the body of the subject, and before and after a visual stimulation, to generate a blood flow index B and send the blood flow index B to the signal processing device;
• the signal processing device, receiving the blood flow index B from the fundus blood flow detection device and the stimulation index S from the optical vision device for analyzing and processing to obtain a retinal neurovascular coupling function index R containing dopamine-related information;
• a computer or a chip receiving the retinal neurovascular coupling function index R from the signal processing device, and analyzing the retinal neurovascular coupling function index R to determine a risk or an outcome of substantia nigra dopaminergic neurodegeneration of a brain.