Cohort Selection for Treatment Evaluation

A computer-implemented method for selecting a patient cohort for a clinical trial comprising:

• retrieving, via a processor and from a secondary storage device storing an electronic medical repository, one or more candidate medical records;
• analyzing, via a processor, historical patient data for an initial population of candidate patients eligible for the clinical trial;
• identifying, via the processor, one or more adverse effect patient characteristics associated with having a severe adverse effect (SAE) or excessive adverse effect (EAE) for the proposed treatment;
• removing, from the initial population of candidate patients and via the processor, any candidate patients identified as having the one or more adverse effect patient characteristics to produce a first subset of eligible candidate patients;
• identifying, via the processor, one or more negative outcome patient characteristics associated with one or more negative treatment outcomes for the proposed treatment;
• removing, from the first subset of eligible candidate patients and via the processor, any candidate patients identified as having the one or more negative outcome patient characteristics to produce a second subset of eligible candidate patients;
• identifying, via the processor, one or more positive outcome patient characteristics associated with one or more positive treatment outcomes for the proposed treatment;
• and
• returning, via the processor, a third subset of eligible candidate patients based on the first and second removing steps and the second identifying step.