System and method for registration of three-dimensional oct/a images to track retinal and choroidal structural changes

Abstract

A system and method for registering OCT/A volumes includes receiving a first OCT/A volume and a second OCT/A volume, generating a first en face angiogram image for the first OCT/A volume and a second en face angiogram image for the second OCT/A volume, determining a lateral transformation coefficient matrix based on the first en face angiogram image and the second en face angiogram image, applying the lateral transformation coefficient matrix to the second OCT/A volume to create a laterally registered second OCT/A volume, determining a depth transformation matrix (DTM) based on the first OCT/A volume and the laterally registered second OCT/A volume, and applying the DTM to the laterally registered second OCT/A volume to create a laterally and axially registered second OCT/A volume. The systema and method may further include creating a 3-D change map based on the first OCT/A volume and the laterally and axially registered second OCT/A volume.

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