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US 2026/0266807 A1Published application
High-brightness fluorescent probes
AssigneeMichigan Technological University
InventorsYoke Khin Yap, Xiuling Liu, Nazmiye Yapici, Dongyan Zhang
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Abstract
A compound includes a nanodot carrier, at least one radical-derived moiety covalently bond with the carrier, and at least one linker having first and second functional groups. The first functional group is linked to the at least one radical-derived moiety, and the second functional group is linked to at least one of a biomolecule, an oligonucleotide, and an aptamer. A method of making a probe is also disclosed.
Claims25
A compound comprising:
- a nanodot carrier;
- at least one radical-derived moiety covalently bond with the carrier;
- at least one linker having first and second functional groups, wherein the first functional group is linked to the at least one radical-derived moiety, and the second functional group is linked to at least one of a biomolecule, an oligonucleotide, and an aptamer.
A method of making a probe, comprising:
- mechanically processing nanodots in polar liquid to create imperfections on the nanodots;
- treating the nanodots to provide polar groups at the imperfections;
- associating radicals with the polar groups at the imperfections;
- and
- linking a linker with the nanodots via one of the associated radicals at a first functional group of the linker.
2 more elements
Dependencies are inferred from the claim text.