Electrospray emitter systems and uses thereof

An electrospray emitter system comprising:

• an emitter;
• a column connected to the emitter;
• a non-conductive emitter collar comprising non-electrically conductive material, wherein at least of a portion of the emitter or the column are positioned within the emitter collar;
• and
• an electrically conductive inner frame, wherein the electrically conductive inner frame is positioned within the emitter collar and around at least a portion of the emitter or the column, and wherein the electrically conductive inner frame provides an electrical path toward the emitter.

An electrospray emitter system comprising:

• an emitter;
• a column connected to the emitter;
• and
• an electrically conductive column holder providing an electrical path toward the emitter, wherein at least a portion of the column interfaces with the column holder.