Modular Electrochemical Sensing System and Method for Parameter Monitoring

A replaceable sensor module, comprising:

• a substrate carrying conductive structures that define electrical interconnects and a reader interface region configured to releasably mate with a reader device;
• a plurality of electrochemical electrodes disposed on the substrate and electrically coupled to the electrical interconnects, the plurality of electrochemical electrodes comprising:
• (a) a plurality of working electrodes comprising a first redundant group of two or more substantially similar ion-selective electrodes, each including chemically selective membrane material configured to generate an electrical response to a first target analyte when exposed to a fluid or porous-media sample, and
• (b) at least one reference electrode comprising a reference couple in ionic communication with an electrolyte reservoir and covered by at least one ion-permeable polymeric membrane configured to regulate ion exchange to maintain reference-potential stability and reduce drift during exposure to a sample of a fluid or porous-media;
• and
• a protective encapsulation layer overlying at least a portion of the conductive structures and defining openings that expose active surfaces of the plurality of electrochemical electrodes while inhibiting fluid ingress to the conductive structures.

A method for monitoring chemical analytes and physical parameters in fluid or porous-media, comprising:

• contacting an interchangeable sensor module with a sample of the fluid or porous-media, the interchangeable sensor module comprising a plurality of electrochemical electrodes, the plurality of electrochemical electrodes comprising at least one reference electrode and a plurality of working electrodes functionalized with chemically selective membrane material configured to generate respective electrical responses to one or more target analytes of the sample;
• interrogating, by an electronic reader, the plurality of electrochemical electrodes with respect to the at least one reference electrode using one or more electrochemical measurement modalities to acquire raw sensor data;
• transmitting, by the electronic reader, the sensor data to a data processing subsystem;
• transforming, by the data processing subsystem, the sensor data into corrected analyte values by applying a trained calibration model configured to compensate for one or more of sensor drift, environmental variability, and cross-ion interference;
• and
• outputting the corrected analyte values for real-time monitoring.