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US 2026/0265755 A1Published application
Conjugate comprising a double stranded rna molecule linked to a single stranded dna molecule
AssigneeArgonaute Rna Limited
InventorsMichael KHAN, Daniel MITCHELL, Johnathan MATLOCK
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Abstract
This disclosure relates to a nucleic acid comprising a double stranded RNA molecule comprising sense and antisense strands and further comprising a single stranded DNA molecule covalently linked to at least the 5′ end of either the sense or antisense RNA part of the molecule.
Claims32
A nucleic acid molecule comprising:
- a first part that comprises a double stranded inhibitory ribonucleic acid (RNA) molecule comprising a sense strand and an antisense strand;
- and
- a second part that comprises a single stranded deoxyribonucleic acid (DNA) molecule, wherein the 3′ end of said single stranded DNA molecule is covalently linked to the 5′ end of the sense strand of the double stranded inhibitory RNA molecule or wherein the 3′ end of the single stranded DNA molecule is covalently linked to the 5′ of the antisense strand of the double stranded inhibitory RNA molecule characterized in that the double stranded inhibitory RNA comprises a sense nucleotide sequence that encodes a part of a human complement component gene and wherein said single stranded DNA molecule comprises a nucleotide sequence that is adapted over at least part of its length to anneal by complementary base pairing to a part of said single stranded DNA to form a double stranded DNA structure comprising a stem and a loop domain and said nucleic acid molecule is linked to N-acetylgalactosamine and said double stranded inhibitory RNA molecule consists of natural nucleotides.
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Dependencies are inferred from the claim text.