Compositions and methods useful for the treatment and management of obesity associated metabolic dysfunction
AssigneeThe Children's Hospital of Philadelphia
InventorDavid Hill
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Abstract
Compositions and methods for the management and treatment of obesity related metabolic dysfunction disorders are disclosed.
Claims29
A composition comprising a hsa-miR6236 or a synthetic, functional variant thereof in a pharmaceutically acceptable carrier for treatment one or more obesity related metabolic disorders in a human subject in need of treatment thereof.
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An exosome pellet, extracellular vessicle, or physiological solution isolated from a biological sample comprising exosomes harboring miRNA6236 or a functional synthetic variant thereof.
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A diagnostic or prognostic method for identifying a subject at altered risk for one or more obesity related metabolic disorders, comprising;
- a) detecting levels of free hsa-miR6236 in circulation or hsa-miR6236 within an extracellular vesicle or endosome in a biological sample obtained from a subject;
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- b) comparing the levels detected in step a) with those from control subjects without disease and from subjects with at least one obesity related metabolic disorder, thereby identifying a subject as being at greater or lesser risk for an obesity disorder.
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Dependencies are inferred from the claim text.