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US 2026/0265703 A1Published application
Degron fusion proteins and methods of production and use thereof
AssigneeBlueRock Therapeutics LP
InventorsConor McAuliffe, Chew-Li Soh, Mark Tomishima
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Abstract
The present disclosure relates in part to degron-based methods for controlling gene-edited therapeutic cells administered to patients, and targeting constructs encoding degrons, which are suitable for generating gene-edited target cells that can be eliminated following administration to a patient.
Claims35
A fusion protein comprising:
- (a) an essential polypeptide;
- (b) a degron;
- and
- (c) optionally;
- a linker.
2 more elements
Dependencies are inferred from the claim text.