System and method for capillary blood stem cell reprogramming using upper-arm blood collection devices for patient-specific disease modeling

Abstract

The present invention discloses a system and method for generating patient-specific induced pluripotent stem cells (iPSCs) from capillary blood collected via upper-arm blood collection devices. The process utilizes specialized devices such as Tasso, Yourbio Health TAP, RedDrop Dx, and Impress to obtain capillary blood without venipuncture, isolates peripheral blood mononuclear cells (PBMCs), and reprograms them into iPSCs using defined factors. The resulting patient-specific iPSCs retain the molecular characteristics of the original donor, enabling advanced in vitro disease modeling, drug discovery, and therapeutic applications. The system integrates artificial intelligence for predictive analysis and supports multiomics studies. This innovation enables “clinical trials in a dish” with patient-matched cells, providing powerful tools for personalized medicine approaches without the ethical concerns associated with embryonic stem cells.

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