Use of a vitisin compound for the production of hematopoietic cells

An in vitro process for producing unipotent erythrocyte progenitors, comprising:

• a) providing multipotent hematopoietic cells, preferably of human origin, selected from the group consisting of hematopoietic stem cells (HSCs), multipotent progenitors (MPPs), common myeloid progenitors (CMPs), megakaryocyte-erythrocyte progenitors (MEPs), and combinations thereof, and optionally amplifying said multipotent hematopoietic cells;
• and
• b) inducing the differentiation of said multipotent hematopoietic cells into unipotent erythrocyte progenitors, and optionally amplifying said unipotent erythrocyte progenitors;
• and
• c) optionally, recovering the unipotent erythrocyte progenitors obtained;
• wherein the cells are placed in contact with a vitisin compound in step a) when it includes the cell amplification step and/or step b).

An in vitro process for producing erythrocytes, comprising:

• a) providing unipotent erythrocyte progenitors;
• b) inducing the differentiation of said unipotent erythrocyte progenitors into unipotent erythrocyte precursors;
• c) inducing the maturation of the erythrocyte precursors into erythrocytes;
• and
• d) optionally recovering the erythrocytes obtained,
• wherein the cells are placed in contact with a vitisin compound in step b) and/or step c).