Constitutive cytokine receptors

Abstract

There is provided herein a recombinant protein comprising an exodomain, at least a portion of which is derived from the extracellular region of EPOR, wherein the exodomain comprises a dimerisation domain allowing dimerisation of said recombinant protein with a second protein and provision of a signal into said T cell in the absence of a signal inducer molecule. Nucleic acid molecules encoding such a recombinant protein, recombinant constructs, vectors and cells containing the nucleic acid molecule, methods of producing such cells, and therapeutic uses thereof are also provided.

Dependencies are inferred from the claim text.