Rna directed method to produce mature retinal pigment epithelial cells for transplantation
AssigneeThe Regents of the University of California
InventorsWilliam Lowry, Steven Daniel Schwartz
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Abstract
The invention disclosed herein provides RNA directed methods to produce mature retinal pigment epithelial cells for transplantation. The invention includes compositions of retinal pigment epithelium (RPE) cells made by these methods, such as autologous induced pluripotent stem cell-derived RPE cells, and their use in treating eye disorders are described.
Claims15
A composition of matter comprising a polycistronic ribonucleotide encoding at least two transcription factor (TF) proteins shown in FIG. 2.
A composition of matter comprising a polycistronic ribonucleotide encoding at least two transcription factor (TF) proteins encoded by SEQ ID NO:
- 1 or SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.