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AssigneesCatholic Kwandong University Industry Foundation, Seoul National University R&Db Foundation
InventorsJi Ho JANG, Young Min CHOI, Jong Kwan JUN, Hye Won SEOL, Ju Won JUNG
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Provided is a genetically engineered human pluripotent cell line wherein an insert sequence including a nucleotide sequence of a fluorescent reporter gene is inserted following a stop codon for the α-MHC gene, whereby the α-MHC gene and the fluorescent reporter gene are co-expressed. By genetically manipulating the cell line to express the fluorescent reporter gene upon expression of the α-MHC gene, which is a myocardial cell marker, it is possible to monitor the differentiation process by observing the fluorescent signal when the cell line is differentiated into myocardial cells.
A genetically engineered human pluripotent cell line wherein an insertion sequence comprising a fluorescent reporter gene sequence is inserted following a stop codon of an α-MHC gene so that the α-MHC gene and the fluorescent reporter gene are co-expressed.
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