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US 2026/0265678 A1Published application
Aerotolerant bacteria fermentation
AssigneeVaxcyte, Inc.
InventorsPeter T. Davey, Namita Bansal, Katherine A. Peffen, Johanna Leslie V. King
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Abstract
Described herein are processes for the fermentation of aerotolerant anaerobic bacteria. Such processes may result improved production and isolation of biomolecules. Isolated biomolecules may include capsular polysaccharides for use in the production of immunogenic compositions.
Claims32
A process for culturing aerotolerant bacteria for production of a biomolecule, the process comprising:
- a) inoculating a culture medium with a colony or preculture of the aerotolerant bacteria in a bioreactor to form a bacterial culture;
- b) supplying the bioreactor with a gaseous mixture substantially free of oxygen, wherein the gaseous mixture comprises at least one of nitrogen (N2) and carbon dioxide (CO2);
- c) incubating the bacterial culture;
- and
- d) maintaining a substantially oxygen-free environment in the bioreactor.
2 more elements
Dependencies are inferred from the claim text.