Deformability of a cell responsive to a pressure wave
AssigneeHewlett-Packard Development Company, L.P.
InventorsFausto D'Apuzzo, Viktor Shkolnikov, Alexander Govyadinov
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Abstract
An example method for measuring deformability of a cell responsive to a pressure wave, consistent with the present disclosure, includes moving a cell of a sample into a cell probing chamber of a microfluidic device. While the cell is in the cell probing chamber, the method includes generating a pressure wave within the cell probing chamber by actuating a fluidic pump. The method further includes determining a deformability of the cell responsive to the pressure wave, using an imaging array synchronized with the actuation of the fluidic pump.
Claims15
An apparatus, comprising:
- a cell source reservoir;
- a cell probing chamber fluidically coupled to the cell source reservoir, the cell probing chamber including:
- a fluidic pump to move a single cell of a sample from the cell source reservoir to the cell probing chamber;
- and a sensor communicatively coupled to the fluidic pump, the sensor to detect a presence of the cell within the cell probing chamber;
- and a controller communicatively coupled to the cell probing chamber, the controller including instructions to:
- actuate the fluidic pump to generate a pressure wave within the cell probing chamber;
- and determine a deformability of the cell responsive to the pressure wave.
An apparatus, comprising:
- a cell source reservoir;
- a cell probing chamber fluidically coupled to the cell source reservoir, the cell probing chamber including:
- a fluidic pump to move a single cell of a sample from the cell source reservoir to the cell probing chamber;
- and a resistor to generate a pressure wave within the cell probing chamber;
- and a controller communicatively coupled to the fluidic pump and the resistor, the controller including instructions to:
- actuate the fluidic pump to move a cell from the cell source reservoir into the cell probing chamber;
- actuate the resistor to generate a pressure wave within the cell probing chamber;
- anddetermine a deformability of the cell responsive to the pressure wave.
Dependencies are inferred from the claim text.