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US 2026/0265405 A1Published application
Anti-mesothelin antibodies
AssigneeNona Biosciences (Suzhou) Co., Ltd.
InventorsMeihong Zhang, Di Wang, Xiaoxiao Wang, Guangkuo Guan, Changjing Deng
Life of this patent
Estimating the term…
Abstract
Provided are antibodies that bind to mesothelin and antigen-binding fragments thereof, as well as uses thereof, nucleic acids encoding the antibodies and antigen-binding fragments, vectors comprising the nucleic acids, and host cell comprising the nucleic acids or the vectors. Also provided are pharmaceutical compositions and conjugates comprising the antibodies, and therapeutic methods by administering the antibodies.
Claims36
An antibody that specifically binds to mesothelin, or an antigen binding fragment thereof, wherein the antibody comprises a light chain variable region (VL) and a heavy chain variable region (VH), and wherein
- (1) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 24, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 27;
- (2) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 25, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 28;
- (3) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 26, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 27;
- (4) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 24, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 29;
- (5) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 24, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 30;
- (6) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 24, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 31;
- (7) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 24, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 32;
- (8) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 24, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 33;
- (9) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 25, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 29;
- (10) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 63, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 67;
- (11) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 64, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 67;
- (12) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 65, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 67;
- (13) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 65, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 68;
- (14) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 63, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 68;
- (15) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 66, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 67;
- (16) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 64, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 69;
- (17) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 66, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 69;
- (18) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 63, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 69;
- or
- (19) the VH comprises the HCDRs 1-3 of a VH having the amino acid sequence set forth in SEQ ID NO:
- 65, and the VL comprises the LCDRs 1-3 of a VL having the amino acid sequence set forth in SEQ ID NO:
- 69.
55 more elements
Dependencies are inferred from the claim text.